3cxm
From Proteopedia
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| - | [[Image:3cxm.png|left|200px]] | ||
| - | + | ==Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil== | |
| - | + | <StructureSection load='3cxm' size='340' side='right'caption='[[3cxm]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3cxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_naiffi Leishmania naiffi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene>, <scene name='pdbligand=URB:5-BROMOPYRIMIDINE-2,4(1H,3H)-DIONE'>URB</scene></td></tr> |
| - | [[3cxm]] is a 1 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxm OCA], [https://pdbe.org/3cxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxm RCSB], [https://www.ebi.ac.uk/pdbsum/3cxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/D0VWU0_9TRYP D0VWU0_9TRYP] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_03166][RuleBase:RU003780] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxm_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxm ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA | + | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Leishmania naiffi]] | [[Category: Leishmania naiffi]] | ||
| - | [[Category: Larson | + | [[Category: Larson ET]] |
| - | [[Category: Merritt | + | [[Category: Merritt EA]] |
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Current revision
Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil
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