1bj5

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[[Image:1bj5.png|left|200px]]
 
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{{STRUCTURE_1bj5| PDB=1bj5 | SCENE= }}
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==HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID==
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<StructureSection load='1bj5' size='340' side='right'caption='[[1bj5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bj5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJ5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9731778}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bj5 OCA], [https://pdbe.org/1bj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1bj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bj5 ProSAT]</span></td></tr>
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[[1bj5]] is a 1 chain structure of [[Albumin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ5 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bj5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bj5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Albumin|Albumin]]
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*[[Albumin 3D structures|Albumin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009731778</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brick, P.]]
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[[Category: Large Structures]]
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[[Category: Curry, S.]]
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[[Category: Brick P]]
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[[Category: Franks, N.]]
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[[Category: Curry S]]
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[[Category: Mandelkow, H.]]
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[[Category: Franks N]]
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[[Category: Lipid-binding]]
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[[Category: Mandelkow H]]
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[[Category: Metal-binding]]
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[[Category: Plasma protein]]
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Current revision

HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID

PDB ID 1bj5

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