3dtc

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[[Image:3dtc.png|left|200px]]
 
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{{STRUCTURE_3dtc| PDB=3dtc | SCENE= }}
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==Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16==
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<StructureSection load='3dtc' size='340' side='right'caption='[[3dtc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DTC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18714982}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIN:12-(2-HYDROXYETHYL)-2-(1-METHYLETHOXY)-13,14-DIHYDRONAPHTHO[2,1-A]PYRROLO[3,4-C]CARBAZOL-5(12H)-ONE'>VIN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dtc OCA], [https://pdbe.org/3dtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dtc RCSB], [https://www.ebi.ac.uk/pdbsum/3dtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dtc ProSAT]</span></td></tr>
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[[3dtc]] is a 1 chain structure of [[Mitogen-activated protein kinase kinase kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DTC OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/M3K9_HUMAN M3K9_HUMAN] May play a role in esophageal cancer susceptibility and/or development.
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== Function ==
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[https://www.uniprot.org/uniprot/M3K9_HUMAN M3K9_HUMAN] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.<ref>PMID:15610029</ref> <ref>PMID:11416147</ref> <ref>PMID:18241037</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/3dtc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dtc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018714982</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Fedorov, A A.]]
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[[Category: Fedorov AA]]
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[[Category: Fedorov, E V.]]
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[[Category: Fedorov EV]]
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[[Category: Hudkins, R L.]]
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[[Category: Hudkins RL]]
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[[Category: Meyer, S L.]]
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[[Category: Meyer SL]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Mixed-lineage kinase]]
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[[Category: Mlk family]]
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[[Category: Mlk1 and mlk3 subtype selective inhibitor]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sh3 domain]]
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[[Category: Transferase]]
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Current revision

Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16

PDB ID 3dtc

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