This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3tu4
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3tu4.png|left|200px]] | ||
| - | + | ==Crystal structure of the Sir3 BAH domain in complex with a nucleosome core particle.== | |
| - | + | <StructureSection load='3tu4' size='340' side='right'caption='[[3tu4]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3tu4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TU4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tu4 OCA], [https://pdbe.org/3tu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tu4 RCSB], [https://www.ebi.ac.uk/pdbsum/3tu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tu4 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3tu4]] is a 12 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
==See Also== | ==See Also== | ||
| - | *[[Histone|Histone]] | + | *[[Histone 3D structures|Histone 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: Saccharomyces cerevisiae | + | [[Category: Saccharomyces cerevisiae S288C]] |
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
| - | [[Category: Armache | + | [[Category: Armache K-J]] |
| - | [[Category: Canzio | + | [[Category: Canzio D]] |
| - | [[Category: Garlick | + | [[Category: Garlick JD]] |
| - | [[Category: Kingston | + | [[Category: Kingston RE]] |
| - | [[Category: Narlikar | + | [[Category: Narlikar GJ]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the Sir3 BAH domain in complex with a nucleosome core particle.
| |||||||||||
