3tu4
From Proteopedia
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| - | [[Image:3tu4.png|left|200px]] | ||
| - | + | ==Crystal structure of the Sir3 BAH domain in complex with a nucleosome core particle.== | |
| - | + | <StructureSection load='3tu4' size='340' side='right'caption='[[3tu4]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3tu4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TU4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tu4 OCA], [https://pdbe.org/3tu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tu4 RCSB], [https://www.ebi.ac.uk/pdbsum/3tu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tu4 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3tu4]] is a 12 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
==See Also== | ==See Also== | ||
| - | *[[Histone|Histone]] | + | *[[Histone 3D structures|Histone 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: Saccharomyces cerevisiae | + | [[Category: Saccharomyces cerevisiae S288C]] |
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
| - | [[Category: Armache | + | [[Category: Armache K-J]] |
| - | [[Category: Canzio | + | [[Category: Canzio D]] |
| - | [[Category: Garlick | + | [[Category: Garlick JD]] |
| - | [[Category: Kingston | + | [[Category: Kingston RE]] |
| - | [[Category: Narlikar | + | [[Category: Narlikar GJ]] |
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Current revision
Crystal structure of the Sir3 BAH domain in complex with a nucleosome core particle.
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