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3cl5

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[[Image:3cl5.png|left|200px]]
 
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{{STRUCTURE_3cl5| PDB=3cl5 | SCENE= }}
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==Structure of coronavirus hemagglutinin-esterase in complex with 4,9-O-diacetyl sialic acid==
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<StructureSection load='3cl5' size='340' side='right'caption='[[3cl5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Structure of coronavirus hemagglutinin-esterase in complex with 4,9-O-diacetyl sialic acid===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cl5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18550812}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIO:METHYL+4,9-DI-O-ACETYL-5-(ACETYLAMINO)-3,5-DIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSIDONIC+ACID'>SIO</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl5 OCA], [https://pdbe.org/3cl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl5 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl5 ProSAT]</span></td></tr>
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[[3cl5]] is a 1 chain structure of [[Hemagglutinin-esterase]] with sequence from [http://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_CVBM HEMA_CVBM] Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cl5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hemagglutinin-esterase|Hemagglutinin-esterase]]
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*[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018550812</ref><references group="xtra"/>
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[[Category: Bovine coronavirus]]
[[Category: Bovine coronavirus]]
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[[Category: Sialate O-acetylesterase]]
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[[Category: Large Structures]]
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[[Category: Groot, R J.de.]]
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[[Category: Huizinga EG]]
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[[Category: Huizinga, E G.]]
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[[Category: Langereis MA]]
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[[Category: Langereis, M A.]]
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[[Category: Zeng QH]]
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[[Category: Vliet, A L.W van.]]
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[[Category: De Groot RJ]]
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[[Category: Zeng, Q H.]]
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[[Category: Van Vliet ALW]]
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[[Category: Envelope protein]]
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[[Category: Glycoprotein]]
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[[Category: Hemagglutinin]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Sgnh-hydrolase fold]]
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[[Category: Swiss roll]]
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[[Category: Transmembrane]]
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[[Category: Virion]]
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Current revision

Structure of coronavirus hemagglutinin-esterase in complex with 4,9-O-diacetyl sialic acid

PDB ID 3cl5

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