3ctr

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[[Image:3ctr.png|left|200px]]
 
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{{STRUCTURE_3ctr| PDB=3ctr | SCENE= }}
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==Crystal structure of the RRM-domain of the poly(A)-specific ribonuclease PARN bound to m7GTP==
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<StructureSection load='3ctr' size='340' side='right'caption='[[3ctr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of the RRM-domain of the poly(A)-specific ribonuclease PARN bound to m7GTP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ctr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CTR FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18694759}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ctr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctr OCA], [https://pdbe.org/3ctr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ctr RCSB], [https://www.ebi.ac.uk/pdbsum/3ctr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ctr ProSAT]</span></td></tr>
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[[3ctr]] is a 1 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CTR OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARN_HUMAN PARN_HUMAN] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.<ref>PMID:9736620</ref> <ref>PMID:10882133</ref> <ref>PMID:11359775</ref> <ref>PMID:12748283</ref> <ref>PMID:15175153</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/3ctr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ctr ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018694759</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dickmanns, A.]]
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[[Category: Large Structures]]
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[[Category: Ficner, R.]]
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[[Category: Dickmanns A]]
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[[Category: Monecke, T.]]
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[[Category: Ficner R]]
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[[Category: Schell, S.]]
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[[Category: Monecke T]]
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[[Category: Exonuclease]]
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[[Category: Schell S]]
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[[Category: Hydrolase]]
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[[Category: M7g-cap]]
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[[Category: M7gtp]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nonsense-mediated mrna decay]]
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[[Category: Nuclease]]
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[[Category: Nucleus]]
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[[Category: Parn]]
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[[Category: Phosphoprotein]]
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[[Category: Protein-rna-complex]]
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[[Category: Rna recognition motif]]
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[[Category: Rna-binding]]
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[[Category: Rrm]]
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Current revision

Crystal structure of the RRM-domain of the poly(A)-specific ribonuclease PARN bound to m7GTP

PDB ID 3ctr

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