1fod

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[[Image:1fod.gif|left|200px]]<br /><applet load="1fod" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fod, resolution 2.6&Aring;" />
 
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'''STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS'''<br />
 
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==Overview==
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==STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS==
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Attachment of foot-and-mouth disease virus (FMDV) to its cellular receptor involves a long and highly antigenic loop containing the conserved sequence, Arg-Gly-Asp, a motif known to be a recognition element in many integrin-dependent cell adhesion processes. In our original crystal structure of FMDV the Arg-Gly-Asp-containing loop ('the loop'), located between beta-strands G and H of capsid protein VP1, was disordered and hence essentially invisible. We previously surmised that its disorder is enhanced by a disulphide bond linking the base of the loop (Cys 134) to Cys 130 of VP2 (ref. 8). We report here the crystal structure of the virus in which this disulphide is reduced. Reduced virus retains infectivity and serological experiments suggest that some of the loop's internal structure is conserved. But here its structure has become sufficiently ordered to allow us to describe an unambiguous conformation, which we relate to some key biological properties of the virus.
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<StructureSection load='1fod' size='340' side='right'caption='[[1fod]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus Foot-and-mouth disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FOD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fod OCA], [https://pdbe.org/1fod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fod RCSB], [https://www.ebi.ac.uk/pdbsum/1fod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fod ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q84771_FMDVO Q84771_FMDVO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/1fod_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fod ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1FOD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus Foot-and-mouth disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOD OCA].
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of a major immunogenic site on foot-and-mouth disease virus., Logan D, Abu-Ghazaleh R, Blakemore W, Curry S, Jackson T, King A, Lea S, Lewis R, Newman J, Parry N, et al., Nature. 1993 Apr 8;362(6420):566-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8385272 8385272]
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[[Category: Foot-and-mouth disease virus]]
[[Category: Foot-and-mouth disease virus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Fry, E.]]
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[[Category: Fry E]]
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[[Category: Lea, S.]]
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[[Category: Lea S]]
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[[Category: Lewis, R.]]
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[[Category: Lewis R]]
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[[Category: Logan, D T.]]
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[[Category: Logan DT]]
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[[Category: Stuart, D.]]
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[[Category: Stuart D]]
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[[Category: icosahedral virus]]
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[[Category: virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:50 2008''
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Current revision

STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS

PDB ID 1fod

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