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2pzn
From Proteopedia
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| - | [[Image:2pzn.png|left|200px]] | ||
| - | + | ==The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant== | |
| - | + | <StructureSection load='2pzn' size='340' side='right'caption='[[2pzn]], [[Resolution|resolution]] 1.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2pzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PZN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=393:(5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC+ACID'>393</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | [[2pzn]] is a 1 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pzn OCA], [https://pdbe.org/2pzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pzn RCSB], [https://www.ebi.ac.uk/pdbsum/2pzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pzn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/2pzn_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pzn ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Aldose | + | *[[Aldose reductase 3D structures|Aldose reductase 3D structures]] |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Darmanin | + | [[Category: Large Structures]] |
| - | [[Category: El-Kabbani | + | [[Category: Darmanin C]] |
| - | [[Category: Hazemann | + | [[Category: El-Kabbani O]] |
| - | [[Category: Joachimiak | + | [[Category: Hazemann I]] |
| - | [[Category: Mitschler | + | [[Category: Joachimiak A]] |
| - | [[Category: Podjarny | + | [[Category: Mitschler A]] |
| - | [[Category: Ruiz | + | [[Category: Podjarny A]] |
| - | [[Category: Zandt | + | [[Category: Ruiz F]] |
| - | + | [[Category: Van Zandt M]] | |
| - | + | ||
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Current revision
The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant
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