3eml

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[[Image:3eml.png|left|200px]]
 
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{{STRUCTURE_3eml| PDB=3eml | SCENE= }}
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==The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.==
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<StructureSection load='3eml' size='340' side='right'caption='[[3eml]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3eml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EML FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eml OCA], [https://pdbe.org/3eml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eml RCSB], [https://www.ebi.ac.uk/pdbsum/3eml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eml ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/3eml_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eml ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The adenosine class of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine. We have determined the crystal structure of the human A2A adenosine receptor, in complex with a high-affinity subtype-selective antagonist, ZM241385, to 2.6 angstrom resolution. Four disulfide bridges in the extracellular domain, combined with a subtle repacking of the transmembrane helices relative to the adrenergic and rhodopsin receptor structures, define a pocket distinct from that of other structurally determined GPCRs. The arrangement allows for the binding of the antagonist in an extended conformation, perpendicular to the membrane plane. The binding site highlights an integral role for the extracellular loops, together with the helical core, in ligand recognition by this class of GPCRs and suggests a role for ZM241385 in restricting the movement of a tryptophan residue important in the activation mechanism of the class A receptors.
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===The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.===
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The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.,Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC Science. 2008 Oct 2. PMID:18832607<ref>PMID:18832607</ref>
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{{ABSTRACT_PUBMED_18832607}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3eml" style="background-color:#fffaf0;"></div>
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[[3eml]] is a 1 chain structure of [[G protein-coupled receptor]] and [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4,_homo_sapiens Homo sapiens, enterobacteria phage t4, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EML OCA].
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==See Also==
==See Also==
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018832607</ref><references group="xtra"/>
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__TOC__
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[[Category: Homo sapiens, enterobacteria phage t4, homo sapiens]]
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</StructureSection>
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
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[[Category: Escherichia virus T4]]
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[[Category: Cherezov, V.]]
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[[Category: Homo sapiens]]
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[[Category: Chien, E Y.T.]]
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[[Category: Large Structures]]
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[[Category: Griffith, M T.]]
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[[Category: Cherezov V]]
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[[Category: Hanson, M A.]]
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[[Category: Chien EYT]]
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[[Category: Ijzerman, A P.]]
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[[Category: Griffith MT]]
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[[Category: Jaakola, V P.]]
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[[Category: Hanson MA]]
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[[Category: Lane, J R.]]
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[[Category: Ijzerman AP]]
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[[Category: Stevens, R C.]]
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[[Category: Jaakola V-P]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Lane JR]]
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[[Category: Adenosine]]
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[[Category: Stevens RC]]
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[[Category: Atcg3d]]
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[[Category: Caffeine]]
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[[Category: Gpcr]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Mesophase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Receptor]]
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[[Category: Structural genomic]]
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Current revision

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.

PDB ID 3eml

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