2cos

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[[Image:2cos.png|left|200px]]
 
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{{STRUCTURE_2cos| PDB=2cos | SCENE= }}
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==Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)==
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<StructureSection load='2cos' size='340' side='right'caption='[[2cos]]' scene=''>
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===Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cos OCA], [https://pdbe.org/2cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cos RCSB], [https://www.ebi.ac.uk/pdbsum/2cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cos ProSAT], [https://www.topsan.org/Proteins/RSGI/2cos TOPSAN]</span></td></tr>
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[[2cos]] is a 1 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COS OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LATS2_MOUSE LATS2_MOUSE] Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).<ref>PMID:15343267</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2cos_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cos ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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[[Category: Mus musculus]]
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== References ==
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[[Category: Non-specific serine/threonine protein kinase]]
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<references/>
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[[Category: Hayashi, F.]]
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__TOC__
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[[Category: Hirota, H.]]
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</StructureSection>
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[[Category: Onuki, H.]]
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[[Category: Large Structures]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama, S.]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Hayashi F]]
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[[Category: Nppsfa]]
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[[Category: Hirota H]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Onuki H]]
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[[Category: Rsgi]]
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[[Category: Yokoyama S]]
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[[Category: Structural genomic]]
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[[Category: Structure genomic]]
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[[Category: Transferase]]
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[[Category: Uba domain]]
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Current revision

Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)

PDB ID 2cos

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