3san

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[[Image:3san.png|left|200px]]
 
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{{STRUCTURE_3san| PDB=3san | SCENE= }}
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==Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir==
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<StructureSection load='3san' size='340' side='right'caption='[[3san]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3san]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Alberta/60/1976(H12N5)) Influenza A virus (A/duck/Alberta/60/1976(H12N5))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3san FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3san OCA], [https://pdbe.org/3san PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3san RCSB], [https://www.ebi.ac.uk/pdbsum/3san PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3san ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A1ILL9_I76A2 A1ILL9_I76A2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.
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===Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir===
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Influenza a virus n5 neuraminidase has an extended 150-cavity.,Wang M, Qi J, Liu Y, Vavricka CJ, Wu Y, Li Q, Gao GF J Virol. 2011 Aug;85(16):8431-5. Epub 2011 Jun 8. PMID:21653672<ref>PMID:21653672</ref>
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{{ABSTRACT_PUBMED_21653672}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3san" style="background-color:#fffaf0;"></div>
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[[3san]] is a 2 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAN OCA].
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==See Also==
==See Also==
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*[[Neuraminidase|Neuraminidase]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021653672</ref><references group="xtra"/>
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__TOC__
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[[Category: Exo-alpha-sialidase]]
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</StructureSection>
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[[Category: Influenza a virus]]
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[[Category: Large Structures]]
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[[Category: Gao, G F.]]
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[[Category: Gao GF]]
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[[Category: Li, Q.]]
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[[Category: Li Q]]
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[[Category: Liu, Y.]]
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[[Category: Liu Y]]
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[[Category: Qi, J X.]]
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[[Category: Qi JX]]
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[[Category: Vavricka, C J.]]
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[[Category: Vavricka CJ]]
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[[Category: Wang, M Y.]]
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[[Category: Wang MY]]
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[[Category: Wu, Y.]]
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[[Category: Wu Y]]
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[[Category: 6-bladed beta-propeller]]
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[[Category: Calcium binding]]
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[[Category: Glycosylation]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir

PDB ID 3san

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