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2ohc

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[[Image:2ohc.png|left|200px]]
 
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{{STRUCTURE_2ohc| PDB=2ohc | SCENE= }}
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==structural and mutational analysis of tRNA-intron splicing endonuclease from Thermoplasma acidophilum DSM1728==
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<StructureSection load='2ohc' size='340' side='right'caption='[[2ohc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===structural and mutational analysis of tRNA-intron splicing endonuclease from Thermoplasma acidophilum DSM1728===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ohc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum_DSM_1728 Thermoplasma acidophilum DSM 1728]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OHC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17827289}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ohc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ohc OCA], [https://pdbe.org/2ohc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ohc RCSB], [https://www.ebi.ac.uk/pdbsum/2ohc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ohc ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2ohc]] is a 2 chain structure of [[Endonuclease]] with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHC OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/ENDA_THEAC ENDA_THEAC] Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/2ohc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ohc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017827289</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Thermoplasma acidophilum]]
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[[Category: Thermoplasma acidophilum DSM 1728]]
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[[Category: TRNA-intron endonuclease]]
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[[Category: Hwang KY]]
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[[Category: Hwang, K Y.]]
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[[Category: Kim YK]]
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[[Category: Kim, Y K.]]
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[[Category: Lee WH]]
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[[Category: Lee, W H.]]
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[[Category: Mizutani K]]
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[[Category: Mizutani, K.]]
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[[Category: Park SY]]
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[[Category: Park, S Y.]]
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[[Category: Rhee KH]]
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[[Category: Rhee, K H.]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: Intron]]
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[[Category: Splicing]]
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[[Category: Trna]]
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Current revision

structural and mutational analysis of tRNA-intron splicing endonuclease from Thermoplasma acidophilum DSM1728

PDB ID 2ohc

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