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1gwz

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[[Image:1gwz.png|left|200px]]
 
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{{STRUCTURE_1gwz| PDB=1gwz | SCENE= }}
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==CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1==
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<StructureSection load='1gwz' size='340' side='right'caption='[[1gwz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9774441}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwz OCA], [https://pdbe.org/1gwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwz RCSB], [https://www.ebi.ac.uk/pdbsum/1gwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwz ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1gwz]] is a 1 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWZ OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gwz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009774441</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Liang, X.]]
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[[Category: Liang X]]
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[[Category: Meng, W.]]
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[[Category: Meng W]]
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[[Category: Niu, T.]]
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[[Category: Niu T]]
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[[Category: Yang, J.]]
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[[Category: Yang J]]
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[[Category: Zhao, Z.]]
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[[Category: Zhao Z]]
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[[Category: Zhou, G W.]]
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[[Category: Zhou GW]]
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[[Category: Catalytic domain]]
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[[Category: Hydrolase]]
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[[Category: Protein tyrosine phosphatase]]
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[[Category: Sh2 domain]]
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[[Category: Wpd loop]]
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Current revision

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1

PDB ID 1gwz

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