This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2rft

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2rft" [edit=sysop:move=sysop])
Current revision (06:32, 3 April 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2rft.png|left|200px]]
 
-
{{STRUCTURE_2rft| PDB=2rft | SCENE= }}
+
==Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog==
-
 
+
<StructureSection load='2rft' size='340' side='right'caption='[[2rft]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
===Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2rft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Hong_Kong/8/1973) Influenza B virus (B/Hong Kong/8/1973)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RFT FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17942670}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rft OCA], [https://pdbe.org/2rft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rft RCSB], [https://www.ebi.ac.uk/pdbsum/2rft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rft ProSAT]</span></td></tr>
-
[[2rft]] is a 2 chain structure of [[Hemagglutinin]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFT OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HEMA_INBHK HEMA_INBHK] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rft_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rft ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Hemagglutinin|Hemagglutinin]]
+
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:017942670</ref><references group="xtra"/>
+
[[Category: Large Structures]]
-
[[Category: Viruses]]
+
[[Category: Chen X]]
-
[[Category: Chen, X.]]
+
[[Category: Ma J]]
-
[[Category: Ma, J.]]
+
[[Category: Tian X]]
-
[[Category: Tian, X.]]
+
[[Category: Wang Q]]
-
[[Category: Wang, Q.]]
+
-
[[Category: Envelope protein]]
+
-
[[Category: Fusion protein]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Hemagglutinin]]
+
-
[[Category: Influenza]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Palmitate]]
+
-
[[Category: Receptor specificity]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Viral protein]]
+
-
[[Category: Virion]]
+

Current revision

Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog

PDB ID 2rft

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rft"
Personal tools