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1c23

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[[Image:1c23.png|left|200px]]
 
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{{STRUCTURE_1c23| PDB=1c23 | SCENE= }}
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==E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHONATE COMPLEX==
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<StructureSection load='1c23' size='340' side='right'caption='[[1c23]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHONATE COMPLEX===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1c23]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C23 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10555963}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c23 OCA], [https://pdbe.org/1c23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c23 RCSB], [https://www.ebi.ac.uk/pdbsum/1c23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c23 ProSAT]</span></td></tr>
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[[1c23]] is a 1 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C23 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/1c23_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c23 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010555963</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Methionyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Honek, J F.]]
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[[Category: Honek JF]]
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[[Category: Lowther, W T.]]
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[[Category: Lowther WT]]
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[[Category: Matthews, B W.]]
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[[Category: Matthews BW]]
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[[Category: Sampson, P B.]]
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[[Category: Sampson PB]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Hydrolase]]
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[[Category: Product complex]]
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Current revision

E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHONATE COMPLEX

PDB ID 1c23

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