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1fo2

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[[Image:1fo2.png|left|200px]]
 
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{{STRUCTURE_1fo2| PDB=1fo2 | SCENE= }}
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==CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN==
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<StructureSection load='1fo2' size='340' side='right'caption='[[1fo2]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FO2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10995765}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMJ:1-DEOXYMANNOJIRIMYCIN'>DMJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fo2 OCA], [https://pdbe.org/1fo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fo2 RCSB], [https://www.ebi.ac.uk/pdbsum/1fo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fo2 ProSAT]</span></td></tr>
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[[1fo2]] is a 1 chain structure of [[Mannosidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FO2 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MA1B1_HUMAN MA1B1_HUMAN] Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15) [MIM:[https://omim.org/entry/614202 614202]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21763484</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MA1B1_HUMAN MA1B1_HUMAN] Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).<ref>PMID:12090241</ref> <ref>PMID:18003979</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/1fo2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fo2 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Mannosidase|Mannosidase]]
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*[[Mannosidase 3D structures|Mannosidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010995765</ref><ref group="xtra">PMID:012202255</ref><references group="xtra"/>
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__TOC__
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[[Category: Alpha-mannosidase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Herscovics, A.]]
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[[Category: Large Structures]]
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[[Category: Howell, P L.]]
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[[Category: Herscovics A]]
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[[Category: Karaveg, K.]]
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[[Category: Howell PL]]
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[[Category: Moremen, K W.]]
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[[Category: Karaveg K]]
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[[Category: Vallee, F.]]
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[[Category: Moremen KW]]
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[[Category: Alpha-alpha7 barrel]]
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[[Category: Vallee F]]
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[[Category: Hydrolase]]
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Current revision

CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN

PDB ID 1fo2

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