2xu5

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[[Image:2xu5.png|left|200px]]
 
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{{STRUCTURE_2xu5| PDB=2xu5 | SCENE= }}
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==CATHEPSIN L WITH A NITRILE INHIBITOR==
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<StructureSection load='2xu5' size='340' side='right'caption='[[2xu5]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===CATHEPSIN L WITH A NITRILE INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XU5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XU5:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]-1-[1-(4-METHYLPHENYL)CYCLOPROPYL]CARBONYL-PYRROLIDINE-2-CARBOXAMIDE'>XU5</scene></td></tr>
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[[2xu5]] is a 1 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU5 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu5 OCA], [https://pdbe.org/2xu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xu5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021184410</ref><references group="xtra"/>
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[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banner, D W.]]
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[[Category: Large Structures]]
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[[Category: Benz, J M.]]
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[[Category: Banner DW]]
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[[Category: Haap, W.]]
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[[Category: Benz JM]]
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[[Category: Drug design]]
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[[Category: Haap W]]
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[[Category: Hydrolase]]
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[[Category: Thiol protease]]
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Current revision

CATHEPSIN L WITH A NITRILE INHIBITOR

PDB ID 2xu5

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