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1s3e

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[[Image:1s3e.png|left|200px]]
 
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{{STRUCTURE_1s3e| PDB=1s3e | SCENE= }}
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==Crystal structure of MAOB in complex with 6-hydroxy-N-propargyl-1(R)-aminoindan==
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<StructureSection load='1s3e' size='340' side='right'caption='[[1s3e]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Crystal structure of MAOB in complex with 6-hydroxy-N-propargyl-1(R)-aminoindan===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S3E FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15027868}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RHP:(3R)-3-(PROP-2-YNYLAMINO)INDAN-5-OL'>RHP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s3e OCA], [https://pdbe.org/1s3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s3e RCSB], [https://www.ebi.ac.uk/pdbsum/1s3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s3e ProSAT]</span></td></tr>
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[[1s3e]] is a 2 chain structure of [[Monoamine oxidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3E OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s3/1s3e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s3e ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Monoamine oxidase|Monoamine oxidase]]
*[[Monoamine oxidase|Monoamine oxidase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015027868</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Monoamine oxidase]]
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[[Category: Large Structures]]
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[[Category: Binda, C.]]
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[[Category: Binda C]]
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[[Category: Edmondson, D E.]]
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[[Category: Edmondson DE]]
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[[Category: Herzig, Y.]]
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[[Category: Herzig Y]]
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[[Category: Hubalek, F.]]
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[[Category: Hubalek F]]
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[[Category: Li, M.]]
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[[Category: Li M]]
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[[Category: Mattevi, A.]]
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[[Category: Mattevi A]]
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[[Category: Sterling, J.]]
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[[Category: Sterling J]]
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[[Category: Enantioselectivity]]
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[[Category: Flavin]]
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[[Category: Human monoamine oxidase]]
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[[Category: Inhibitor binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rasagiline]]
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Current revision

Crystal structure of MAOB in complex with 6-hydroxy-N-propargyl-1(R)-aminoindan

PDB ID 1s3e

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