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1gmy

From Proteopedia

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[[Image:1gmy.png|left|200px]]
 
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{{STRUCTURE_1gmy| PDB=1gmy | SCENE= }}
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==Cathepsin B complexed with dipeptidyl nitrile inhibitor==
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<StructureSection load='1gmy' size='340' side='right'caption='[[1gmy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===CATHEPSIN B COMPLEXED WITH DIPEPTIDYL NITRILE INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gmy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GMY FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11741472}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEM:2-AMINOETHANIMIDIC+ACID'>AEM</scene>, <scene name='pdbligand=APD:3-METHYLPHENYLALANINE'>APD</scene>, <scene name='pdbligand=DFA:DIPHENYLACETIC+ACID'>DFA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gmy OCA], [https://pdbe.org/1gmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gmy RCSB], [https://www.ebi.ac.uk/pdbsum/1gmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gmy ProSAT]</span></td></tr>
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[[1gmy]] is a 3 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMY OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gmy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gmy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011741472</ref><references group="xtra"/>
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[[Category: Cathepsin B]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bohacek, R S.]]
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[[Category: Large Structures]]
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[[Category: Capparelli, M P.]]
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[[Category: Bohacek RS]]
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[[Category: Clark, K L.]]
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[[Category: Capparelli MP]]
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[[Category: Coppa, D E.]]
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[[Category: Clark KL]]
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[[Category: Cowen, S D.]]
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[[Category: Coppa DE]]
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[[Category: Doughty, J R.]]
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[[Category: Cowen SD]]
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[[Category: Du, Z.]]
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[[Category: Doughty JR]]
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[[Category: Duzer, J H.Van.]]
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[[Category: Du Z]]
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[[Category: Fang, Z.]]
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[[Category: Fang Z]]
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[[Category: Farley, D L.]]
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[[Category: Farley DL]]
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[[Category: Fitt, J J.]]
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[[Category: Fitt JJ]]
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[[Category: Goldberg, R L.]]
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[[Category: Goldberg RL]]
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[[Category: Goldstein, R.]]
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[[Category: Goldstein R]]
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[[Category: Greenspan, P D.]]
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[[Category: Greenspan PD]]
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[[Category: Knap, A K.]]
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[[Category: Knap AK]]
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[[Category: Macchia, W.]]
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[[Category: Macchia W]]
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[[Category: Mcquire, L W.]]
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[[Category: McQuire LW]]
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[[Category: Tommasi, R A.]]
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[[Category: Tommasi RA]]
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[[Category: Wigg, A M.]]
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[[Category: Wigg AM]]
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[[Category: Zhou, H.]]
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[[Category: Zhou H]]
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[[Category: Zhu, L.]]
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[[Category: Zhu L]]
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[[Category: Cathepsin b]]
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[[Category: Van Duzer JH]]
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[[Category: Covalent complex]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-inhibitor complex]]
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[[Category: Hydrolase/inhibitor]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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Current revision

Cathepsin B complexed with dipeptidyl nitrile inhibitor

PDB ID 1gmy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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