1mfp

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[[Image:1mfp.png|left|200px]]
 
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{{STRUCTURE_1mfp| PDB=1mfp | SCENE= }}
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==E. coli Enoyl Reductase in complex with NAD and SB611113==
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<StructureSection load='1mfp' size='340' side='right'caption='[[1mfp]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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===E. coli Enoyl Reductase in complex with NAD and SB611113===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mfp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12699381}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDN:(E)-N-METHYL-N-(1-METHYL-1H-INDOL-3-YLMETHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-3-YL)-ACRYLAMIDE'>IDN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfp OCA], [https://pdbe.org/1mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mfp RCSB], [https://www.ebi.ac.uk/pdbsum/1mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfp ProSAT]</span></td></tr>
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[[1mfp]] is a 2 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mfp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mfp ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012699381</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Burgess, W J.]]
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[[Category: Large Structures]]
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[[Category: DeWolf, W E.]]
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[[Category: Burgess WJ]]
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[[Category: Elkins, P A.]]
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[[Category: DeWolf Jr WE]]
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[[Category: Head, M S.]]
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[[Category: Elkins PA]]
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[[Category: Huffman, W F.]]
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[[Category: Head MS]]
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[[Category: Jakas, D R.]]
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[[Category: Huffman WF]]
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[[Category: Janson, C A.]]
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[[Category: Jakas DR]]
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[[Category: Keller, P M.]]
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[[Category: Janson CA]]
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[[Category: Manley, P J.]]
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[[Category: Keller PM]]
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[[Category: Miller, W H.]]
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[[Category: Manley PJ]]
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[[Category: Moore, T D.]]
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[[Category: Miller WH]]
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[[Category: Newlander, K A.]]
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[[Category: Moore TD]]
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[[Category: Payne, D J.]]
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[[Category: Newlander KA]]
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[[Category: Pearson, S.]]
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[[Category: Payne DJ]]
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[[Category: Polizzi, B J.]]
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[[Category: Pearson S]]
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[[Category: Qiu, X.]]
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[[Category: Polizzi BJ]]
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[[Category: Rittenhouse, S F.]]
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[[Category: Qiu X]]
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[[Category: Seefeld, M A.]]
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[[Category: Rittenhouse SF]]
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[[Category: Uzinskas, I N.]]
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[[Category: Seefeld MA]]
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[[Category: Wallis, N G.]]
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[[Category: Uzinskas IN]]
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[[Category: Enoyl reductase]]
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[[Category: Wallis NG]]
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[[Category: Enoyl-acp reductase]]
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[[Category: Fabi]]
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[[Category: Oxidoreductase]]
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Current revision

E. coli Enoyl Reductase in complex with NAD and SB611113

PDB ID 1mfp

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