2ea1

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[[Image:2ea1.png|left|200px]]
 
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{{STRUCTURE_2ea1| PDB=2ea1 | SCENE= }}
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==Crystal structure of Ribonuclease I from Escherichia coli COMPLEXED WITH GUANYLYL-2(PRIME),5(PRIME)-GUANOSINE==
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<StructureSection load='2ea1' size='340' side='right'caption='[[2ea1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of Ribonuclease I from Escherichia coli COMPLEXED WITH GUANYLYL-2(PRIME),5(PRIME)-GUANOSINE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ea1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EA1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11368513}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GPG:GUANYLYL-2,5-PHOSPHOGUANOSINE'>GPG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ea1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ea1 OCA], [https://pdbe.org/2ea1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ea1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ea1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ea1 ProSAT]</span></td></tr>
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[[2ea1]] is a 1 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EA1 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNI_ECOLI RNI_ECOLI] One of the few RNases that cleaves the phosphodiester bond between any two nucleotide. Shows a preference for cytidylic or guanylic acid.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2ea1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ea1 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011368513</ref><ref group="xtra">PMID:002541256</ref><references group="xtra"/>
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[[Category: Enterobacter ribonuclease]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Lim, L W.]]
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[[Category: Large Structures]]
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[[Category: Lim, R W.]]
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[[Category: Lim LW]]
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[[Category: Padmanabhan, S.]]
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[[Category: Lim RW]]
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[[Category: Pan, J.]]
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[[Category: Padmanabhan S]]
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[[Category: Zhou, K.]]
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[[Category: Pan J]]
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[[Category: Hydrolase]]
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[[Category: Zhou K]]
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[[Category: Protein-gpg complex]]
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Current revision

Crystal structure of Ribonuclease I from Escherichia coli COMPLEXED WITH GUANYLYL-2(PRIME),5(PRIME)-GUANOSINE

PDB ID 2ea1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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