1hv5

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[[Image:1hv5.png|left|200px]]
 
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{{STRUCTURE_1hv5| PDB=1hv5 | SCENE= }}
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==CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR==
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<StructureSection load='1hv5' size='340' side='right'caption='[[1hv5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hv5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11254383}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=RXP:1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC+ACID'>RXP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv5 OCA], [https://pdbe.org/1hv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv5 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv5 ProSAT]</span></td></tr>
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[[1hv5]] is a 6 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP11_MOUSE MMP11_MOUSE] May play an important role in the progression of epithelial malignancies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/1hv5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hv5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011254383</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Basset, P.]]
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[[Category: Basset P]]
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[[Category: Cuniasse, P.]]
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[[Category: Cuniasse P]]
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[[Category: Dive, V.]]
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[[Category: Dive V]]
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[[Category: Gall, A L.]]
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[[Category: Gall AL]]
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[[Category: Kannan, R.]]
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[[Category: Kannan R]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Rio, M C.]]
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[[Category: Rio MC]]
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[[Category: Ruff, M.]]
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[[Category: Ruff M]]
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[[Category: Yiotakis, A.]]
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[[Category: Yiotakis A]]
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[[Category: Hydrolase]]
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[[Category: Inhibition]]
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[[Category: Phosphinic inhibitor]]
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[[Category: Stromelysin-3]]
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Current revision

CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR

PDB ID 1hv5

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