3dac

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[[Image:3dac.png|left|200px]]
 
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{{STRUCTURE_3dac| PDB=3dac | SCENE= }}
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==Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain==
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<StructureSection load='3dac' size='340' side='right'caption='[[3dac]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dac]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dac OCA], [https://pdbe.org/3dac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dac RCSB], [https://www.ebi.ac.uk/pdbsum/3dac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dac ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDM4_DANRE MDM4_DANRE] Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dac_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dac ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.
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===Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain===
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Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.,Popowicz GM, Czarna A, Holak TA Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27. PMID:18677113<ref>PMID:18677113</ref>
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{{ABSTRACT_PUBMED_18677113}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3dac" style="background-color:#fffaf0;"></div>
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[[3dac]] is a 4 chain structure of [[MDM4]] with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAC OCA].
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==See Also==
==See Also==
*[[MDM4|MDM4]]
*[[MDM4|MDM4]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018677113</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Czarna, A.]]
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[[Category: Homo sapiens]]
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[[Category: Holak, T A.]]
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[[Category: Large Structures]]
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[[Category: Popowicz, G M.]]
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[[Category: Czarna A]]
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[[Category: Apoptosis]]
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[[Category: Holak TA]]
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[[Category: Cell cycle]]
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[[Category: Popowicz GM]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Hdm2]]
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[[Category: Hdm4]]
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[[Category: Hdmx]]
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[[Category: Mdm-4]]
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[[Category: Mdm-x]]
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[[Category: Mdm2]]
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[[Category: Mdm4]]
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[[Category: Mdmx]]
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[[Category: Nucleus]]
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[[Category: Oncogene]]
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[[Category: P53]]
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[[Category: Transcription]]
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[[Category: Tumor]]
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Current revision

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

PDB ID 3dac

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