2kzr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2kzr" [edit=sysop:move=sysop])
Current revision (05:38, 15 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2kzr.png|left|200px]]
 
-
{{STRUCTURE_2kzr| PDB=2kzr | SCENE= }}
+
==Solution NMR Structure of Ubiquitin thioesterase OTU1 (EC 3.1.2.-) from Mus musculus, Northeast Structural Genomics Consortium Target MmT2A==
-
 
+
<StructureSection load='2kzr' size='340' side='right'caption='[[2kzr]]' scene=''>
-
===Solution NMR Structure of Ubiquitin thioesterase OTU1 (EC 3.1.2.-) from Mus musculus, Northeast Structural Genomics Consortium Target MmT2A===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2kzr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZR FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzr OCA], [https://pdbe.org/2kzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzr RCSB], [https://www.ebi.ac.uk/pdbsum/2kzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzr ProSAT]</span></td></tr>
-
[[2kzr]] is a 1 chain structure of [[Thioesterase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZR OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/OTU1_MOUSE OTU1_MOUSE] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kzr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kzr ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Thioesterase|Thioesterase]]
+
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bezsonova, I.]]
+
[[Category: Bezsonova I]]
-
[[Category: Chitayat, S.]]
+
[[Category: Chitayat S]]
-
[[Category: Dhe-Paganon, S.]]
+
[[Category: Dhe-Paganon S]]
-
[[Category: Doherty, R S.]]
+
[[Category: Doherty RS]]
-
[[Category: Gutmanas, A.]]
+
[[Category: Gutmanas A]]
-
[[Category: Lemak, A.]]
+
[[Category: Lemak A]]
-
[[Category: Montelione, G T.]]
+
[[Category: Montelione GT]]
-
[[Category: NESG, Northeast Structural Genomics Consortium.]]
+
[[Category: Semesi A]]
-
[[Category: Semesi, A.]]
+
[[Category: Wu B]]
-
[[Category: Wu, B.]]
+
[[Category: Yee A]]
-
[[Category: Yee, A.]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi-2]]
+
-
[[Category: Structural genomic]]
+

Current revision

Solution NMR Structure of Ubiquitin thioesterase OTU1 (EC 3.1.2.-) from Mus musculus, Northeast Structural Genomics Consortium Target MmT2A

PDB ID 2kzr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kzr"
Personal tools