3m6l

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[[Image:3m6l.png|left|200px]]
 
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{{STRUCTURE_3m6l| PDB=3m6l | SCENE= }}
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==Crystal structure of transketolase in complex with thiamine diphosphate, ribose-5-phosphate and calcium ion==
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<StructureSection load='3m6l' size='340' side='right'caption='[[3m6l]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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===Crystal structure of transketolase in complex with thiamine diphosphate, ribose-5-phosphate and calcium ion===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m6l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M6L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=R5P:RIBOSE-5-PHOSPHATE'>R5P</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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[[3m6l]] is a 1 chain structure of [[Transketolase]] with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6L OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m6l OCA], [https://pdbe.org/3m6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m6l RCSB], [https://www.ebi.ac.uk/pdbsum/3m6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m6l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0P7Y3_CAMJE Q0P7Y3_CAMJE] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity).[RuleBase:RU004996]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/3m6l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m6l ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Transketolase|Transketolase]]
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*[[Transketolase 3D structures|Transketolase 3D structures]]
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[[Category: Campylobacter jejuni]]
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__TOC__
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[[Category: Transketolase]]
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</StructureSection>
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[[Category: Anderson, W.]]
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[[Category: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]]
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[[Category: Csgid]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A.]]
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[[Category: Anderson W]]
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[[Category: Makowska-Grzyska, M.]]
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[[Category: Joachimiak A]]
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[[Category: Maltseva, N.]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Nocek, B.]]
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[[Category: Maltseva N]]
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[[Category: Calcium binding]]
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[[Category: Nocek B]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Csgid]]
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[[Category: Niaid]]
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[[Category: Ribose-5-phosphate bound]]
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[[Category: Structural genomic]]
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[[Category: Thiamine pyrophosphate]]
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[[Category: Transferase]]
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[[Category: Transketolase]]
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Current revision

Crystal structure of transketolase in complex with thiamine diphosphate, ribose-5-phosphate and calcium ion

PDB ID 3m6l

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