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1ex9

From Proteopedia

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[[Image:1ex9.png|left|200px]]
 
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{{STRUCTURE_1ex9| PDB=1ex9 | SCENE= }}
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==CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LIPASE COMPLEXED WITH RC-(RP,SP)-1,2-DIOCTYLCARBAMOYL-GLYCERO-3-O-OCTYLPHOSPHONATE==
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<StructureSection load='1ex9' size='340' side='right'caption='[[1ex9]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LIPASE COMPLEXED WITH RC-(RP,SP)-1,2-DIOCTYLCARBAMOYL-GLYCERO-3-O-OCTYLPHOSPHONATE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ex9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EX9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10893416}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=OCP:OCTYL-PHOSPHINIC+ACID+1,2-BIS-OCTYLCARBAMOYLOXY-ETHYL+ESTER'>OCP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ex9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex9 OCA], [https://pdbe.org/1ex9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ex9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ex9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex9 ProSAT]</span></td></tr>
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[[1ex9]] is a 1 chain structure of [[Lipase]] with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX9 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIP_PSEAE LIP_PSEAE] Catalyzes the hydrolysis of triglycerides. Catalyzes the synthesis of macrocyclic lactones in anhydrous organic solvents.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1ex9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ex9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Lipase|Lipase]]
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*[[Lipase 3D Structures|Lipase 3D Structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010893416</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Triacylglycerol lipase]]
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[[Category: Dijkstra BW]]
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[[Category: Dijkstra, B W.]]
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[[Category: Jaeger K-E]]
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[[Category: Jaeger, K E.]]
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[[Category: Lang DA]]
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[[Category: Lang, D A.]]
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[[Category: Liebeton K]]
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[[Category: Liebeton, K.]]
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[[Category: Nardini M]]
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[[Category: Nardini, M.]]
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[[Category: Alpha-beta hydrolase fold]]
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[[Category: Hydrolase]]
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[[Category: Lipase]]
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[[Category: Phosphonate inhibitor]]
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[[Category: Pseudomona]]
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Current revision

CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LIPASE COMPLEXED WITH RC-(RP,SP)-1,2-DIOCTYLCARBAMOYL-GLYCERO-3-O-OCTYLPHOSPHONATE

PDB ID 1ex9

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OCA

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