2xik

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[[Image:2xik.png|left|200px]]
 
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{{STRUCTURE_2xik| PDB=2xik | SCENE= }}
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==Structure of Human YSK1 (Yeast Sps1-Ste20-related Kinase 1)==
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<StructureSection load='2xik' size='340' side='right'caption='[[2xik]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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===STRUCTURE OF HUMAN YSK1 (YEAST SPS1-STE20-RELATED KINASE 1)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XIK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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[[2xik]] is a 1 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIK OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xik OCA], [https://pdbe.org/2xik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xik RCSB], [https://www.ebi.ac.uk/pdbsum/2xik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xik ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STK25_HUMAN STK25_HUMAN] Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.<ref>PMID:15037601</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/2xik_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xik ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Allerston, C.]]
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[[Category: Allerston C]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Brenner, B.]]
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[[Category: Brenner B]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad A]]
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[[Category: Daga, N.]]
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[[Category: Daga N]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins JM]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Mahajan, P.]]
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[[Category: Mahajan P]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz JRC]]
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[[Category: Rellos, P.]]
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[[Category: Rellos P]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky P]]
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[[Category: Shrestha, B.]]
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[[Category: Shrestha B]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu E]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar M]]
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[[Category: Vondelft, F.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Kinase1]]
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[[Category: Transferase]]
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[[Category: Ysk1]]
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Current revision

Structure of Human YSK1 (Yeast Sps1-Ste20-related Kinase 1)

PDB ID 2xik

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