2l5a

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[[Image:2l5a.png|left|200px]]
 
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{{STRUCTURE_2l5a| PDB=2l5a | SCENE= }}
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==Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3==
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<StructureSection load='2l5a' size='340' side='right'caption='[[2l5a]]' scene=''>
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===Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l5a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5A FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21412236}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5a OCA], [https://pdbe.org/2l5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5a RCSB], [https://www.ebi.ac.uk/pdbsum/2l5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5a ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2l5a]] is a 1 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5A OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SCM3_YEAST SCM3_YEAST] Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.[UniProtKB:Q8NCD3][https://www.uniprot.org/uniprot/CENPA_YEAST CENPA_YEAST] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for functional chromatin architecture at the yeast 2-micron circle partitioning locus and promotes equal plasmid segregation.<ref>PMID:7698647</ref> <ref>PMID:9741625</ref> <ref>PMID:9584087</ref> <ref>PMID:10454560</ref> <ref>PMID:11063678</ref> <ref>PMID:10891506</ref> <ref>PMID:10499801</ref> <ref>PMID:11606525</ref> <ref>PMID:15590827</ref> <ref>PMID:16207811</ref> <ref>PMID:16966420</ref> [https://www.uniprot.org/uniprot/H4_YEAST H4_YEAST]
==See Also==
==See Also==
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*[[Histone|Histone]]
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*[[Histone 3D structures|Histone 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021412236</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Bai, Y.]]
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[[Category: Bai Y]]
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[[Category: Feng, H.]]
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[[Category: Feng H]]
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[[Category: Ghirlando, R.]]
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[[Category: Ghirlando R]]
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[[Category: Hu, K.]]
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[[Category: Hu K]]
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[[Category: Jenkins, L.]]
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[[Category: Jenkins L]]
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[[Category: Tjandra, N.]]
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[[Category: Tjandra N]]
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[[Category: Wu, C.]]
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[[Category: Wu C]]
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[[Category: Xiao, H.]]
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[[Category: Xiao H]]
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[[Category: Zhou, B.]]
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[[Category: Zhou B]]
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[[Category: Zhou, Z.]]
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[[Category: Zhou Z]]
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[[Category: Zwolak, A.]]
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[[Category: Zwolak A]]
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[[Category: A single chain of cse4+scm3+h4]]
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[[Category: Chimera protein]]
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[[Category: Fusion protein]]
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[[Category: Nuclear protein]]
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Current revision

Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3

PDB ID 2l5a

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