2uw2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2uw2" [edit=sysop:move=sysop])
Current revision (09:52, 9 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2uw2.png|left|200px]]
 
-
{{STRUCTURE_2uw2| PDB=2uw2 | SCENE= }}
+
==Crystal structure of human ribonucleotide reductase subunit R2==
-
 
+
<StructureSection load='2uw2' size='340' side='right'caption='[[2uw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
===CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE SUBUNIT R2===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2uw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UW2 FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-
[[2uw2]] is a 1 chain structure of [[Ribonucleotide reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uw2 OCA], [https://pdbe.org/2uw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uw2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RIR2_HUMAN RIR2_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uw2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uw2 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Ribonucleotide reductase|Ribonucleotide reductase]]
+
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ribonucleoside-diphosphate reductase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Berg, S Van Den.]]
+
[[Category: Berglund H]]
-
[[Category: Berglund, H.]]
+
[[Category: Busam R]]
-
[[Category: Busam, R.]]
+
[[Category: Collins R]]
-
[[Category: Collins, R.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Ehn M]]
-
[[Category: Ehn, M.]]
+
[[Category: Flodin S]]
-
[[Category: Flodin, S.]]
+
[[Category: Flores A]]
-
[[Category: Flores, A.]]
+
[[Category: Graslund S]]
-
[[Category: Graslund, S.]]
+
[[Category: Hallberg BM]]
-
[[Category: Hallberg, B M.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Hogbom M]]
-
[[Category: Hogbom, M.]]
+
[[Category: Holmberg Schiavone L]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Kotenyova T]]
-
[[Category: Magnusdottir, A.]]
+
[[Category: Magnusdottir A]]
-
[[Category: Moche, M.]]
+
[[Category: Moche M]]
-
[[Category: Nilsson-Ehle, P.]]
+
[[Category: Nilsson-Ehle P]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nordlund P]]
-
[[Category: Nyman, T.]]
+
[[Category: Nyman T]]
-
[[Category: Ogg, D.]]
+
[[Category: Ogg D]]
-
[[Category: Persson, C.]]
+
[[Category: Persson C]]
-
[[Category: Sagemark, J.]]
+
[[Category: Sagemark J]]
-
[[Category: Schiavone, L Holmberg.]]
+
[[Category: Stenmark P]]
-
[[Category: Stenmark, P.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Thorsell AG]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Uppenberg J]]
-
[[Category: Uppenberg, J.]]
+
[[Category: Van Den Berg S]]
-
[[Category: Wallden, K.]]
+
[[Category: Wallden K]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Welin, M.]]
+
[[Category: Welin M]]
-
[[Category: Diiron]]
+
-
[[Category: Dna replication]]
+
-
[[Category: Iron]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: R2]]
+
-
[[Category: R2 subunit]]
+
-
[[Category: Radical]]
+
-
[[Category: Ribonucleotide reductase]]
+
-
[[Category: Small subunit ribonucleotide reductase]]
+

Current revision

Crystal structure of human ribonucleotide reductase subunit R2

PDB ID 2uw2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2uw2"
Personal tools