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3rgf

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[[Image:3rgf.png|left|200px]]
 
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{{STRUCTURE_3rgf| PDB=3rgf | SCENE= }}
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==Crystal Structure of human CDK8/CycC==
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<StructureSection load='3rgf' size='340' side='right'caption='[[3rgf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal Structure of human CDK8/CycC===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGF FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21806996}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAX:4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE'>BAX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgf OCA], [https://pdbe.org/3rgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgf RCSB], [https://www.ebi.ac.uk/pdbsum/3rgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgf ProSAT]</span></td></tr>
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[[3rgf]] is a 2 chain structure of [[Cyclin-dependent kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGF OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDK8_HUMAN CDK8_HUMAN] Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.<ref>PMID:10993082</ref> <ref>PMID:15546612</ref>
==See Also==
==See Also==
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*[[Cyclin-dependent kinase|Cyclin-dependent kinase]]
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*[[Cyclin 3D structures|Cyclin 3D structures]]
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*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:021806996</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blaesse, M.]]
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[[Category: Large Structures]]
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[[Category: Boettcher, J.]]
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[[Category: Blaesse M]]
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[[Category: Huber, R.]]
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[[Category: Boettcher J]]
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[[Category: Maskos, K.]]
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[[Category: Huber R]]
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[[Category: Schneider, E V.]]
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[[Category: Maskos K]]
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[[Category: Protein kinase complex]]
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[[Category: Schneider EV]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of human CDK8/CycC

PDB ID 3rgf

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