3ej8

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[[Image:3ej8.png|left|200px]]
 
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{{STRUCTURE_3ej8| PDB=3ej8 | SCENE= }}
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==Structure of double mutant of human iNOS oxygenase domain with bound immidazole==
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<StructureSection load='3ej8' size='340' side='right'caption='[[3ej8]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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===Structure of double mutant of human iNOS oxygenase domain with bound immidazole===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ej8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EJ8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18849972}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ej8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ej8 OCA], [https://pdbe.org/3ej8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ej8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ej8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ej8 ProSAT]</span></td></tr>
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[[3ej8]] is a 4 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJ8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/3ej8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ej8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018849972</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Aberg, A.]]
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[[Category: Aberg A]]
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[[Category: Andersson, G.]]
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[[Category: Andersson G]]
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[[Category: Andrews, G.]]
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[[Category: Andrews G]]
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[[Category: Arvai, A S.]]
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[[Category: Arvai AS]]
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[[Category: Cheshire, D R.]]
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[[Category: Cheshire DR]]
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[[Category: Connolly, S.]]
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[[Category: Connolly S]]
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[[Category: Crane, B R.]]
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[[Category: Crane BR]]
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[[Category: Garcin, E D.]]
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[[Category: Garcin ED]]
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[[Category: Gensmantel, N P.]]
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[[Category: Gensmantel NP]]
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[[Category: Getzoff, E D.]]
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[[Category: Getzoff ED]]
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[[Category: Hamley, P J.]]
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[[Category: Hamley PJ]]
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[[Category: Kroeger, M D.]]
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[[Category: Kroeger MD]]
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[[Category: Mallinder, P R.]]
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[[Category: Mallinder PR]]
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[[Category: Mete, A.]]
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[[Category: Mete A]]
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[[Category: Nicholls, D J.]]
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[[Category: Nicholls DJ]]
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[[Category: Rosenfeld, R J.]]
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[[Category: Rosenfeld RJ]]
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[[Category: St-Gallay, S A.]]
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[[Category: St-Gallay SA]]
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[[Category: Stuehr, D J.]]
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[[Category: Stuehr DJ]]
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[[Category: Tainer, J A.]]
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[[Category: Tainer JA]]
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[[Category: Tinker, A C.]]
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[[Category: Tinker AC]]
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[[Category: Wallace, A V.]]
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[[Category: Wallace AV]]
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[[Category: Fad]]
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[[Category: Fmn]]
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[[Category: Heme]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Nadp]]
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[[Category: Nitric oxide synthase]]
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[[Category: No]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase calmodulin-binding]]
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[[Category: Tetrahydrobiopterin]]
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Current revision

Structure of double mutant of human iNOS oxygenase domain with bound immidazole

PDB ID 3ej8

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Proteopedia Page Contributors and Editors (what is this?)

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