3px7

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[[Image:3px7.png|left|200px]]
 
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{{STRUCTURE_3px7| PDB=3px7 | SCENE= }}
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==Crystal Structure of covalent complex of topoisomerase 1A with substrate==
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<StructureSection load='3px7' size='340' side='right'caption='[[3px7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal Structure of covalent complex of topoisomerase 1A with substrate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3px7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH1 Escherichia coli DH1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PX7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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[[3px7]] is a 3 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_dh1 Escherichia coli dh1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX7 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3px7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3px7 OCA], [https://pdbe.org/3px7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3px7 RCSB], [https://www.ebi.ac.uk/pdbsum/3px7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3px7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOP1_ECOLI TOP1_ECOLI] Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.<ref>PMID:9497321</ref> <ref>PMID:10681504</ref> <ref>PMID:21482796</ref>
==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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[[Category: DNA topoisomerase]]
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== References ==
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[[Category: Escherichia coli dh1]]
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<references/>
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[[Category: Cheng, B.]]
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__TOC__
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[[Category: Tse-dinh, Y C.]]
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</StructureSection>
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[[Category: Zhang, Z.]]
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[[Category: Escherichia coli DH1]]
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[[Category: Isomerase]]
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[[Category: Large Structures]]
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[[Category: Isomerase-dna complex]]
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[[Category: Cheng B]]
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[[Category: Topoisomerase]]
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[[Category: Tse-dinh YC]]
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[[Category: Zhang Z]]

Current revision

Crystal Structure of covalent complex of topoisomerase 1A with substrate

PDB ID 3px7

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