This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1fq8
From Proteopedia
(Difference between revisions)
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1fq8.png|left|200px]] | ||
| - | + | ==X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN== | |
| - | + | <StructureSection load='1fq8' size='340' side='right'caption='[[1fq8]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1fq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FQ8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2Y4:N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-CYCLOHEXYL-4,4-DIFLUORO-3-HYDROXY-5-(METHYLAMINO)-5-OXO-PENTAN-2-YL]AMINO]-1-OXO-HEXAN-2-YL]AMINO]-1-OXO-3-PHENYL-PROPAN-2-YL]MORPHOLINE-4-CARBOXAMIDE'>2Y4</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fq8 OCA], [https://pdbe.org/1fq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1fq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fq8 ProSAT]</span></td></tr> |
| - | [[1fq8]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CARP_YEAST CARP_YEAST] Aspartyl protease implicated in the post-translational regulation of S.cerevisiae vacuolar proteinases. Acts on YSCB, on YSCY and on itself. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/1fq8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fq8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Pepsin|Pepsin]] | *[[Pepsin|Pepsin]] | ||
| - | + | *[[Proteinase 3D structures|Proteinase 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | + | [[Category: Badasso MO]] | |
| - | [[Category: Badasso | + | [[Category: Cooper JB]] |
| - | [[Category: Cooper | + | [[Category: Cronin NB]] |
| - | [[Category: Cronin | + | [[Category: Dreyer T]] |
| - | [[Category: Dreyer | + | [[Category: Hoover DJ]] |
| - | [[Category: Hoover | + | [[Category: Humblet CC]] |
| - | [[Category: Humblet | + | [[Category: Lunney EA]] |
| - | [[Category: Lunney | + | [[Category: Rosati RL]] |
| - | [[Category: Rosati | + | [[Category: Tickle IJ]] |
| - | [[Category: Tickle | + | |
| - | + | ||
Current revision
X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN
| |||||||||||
