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1g5z

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[[Image:1g5z.jpg|left|200px]]<br /><applet load="1g5z" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1g5z, resolution 2.51&Aring;" />
 
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'''CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40==
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The outer surface protein C (OspC) is one of the major host-induced antigens of Borrelia burgdorferi, the causative agent of Lyme disease. We have solved the crystal structure of recombinant OspC to a resolution of 2.5 A. OspC, a largely alpha-helical protein, is a dimer with a characteristic central four-helical bundle formed by association of the two longest helices from each subunit. OspC is very different from OspA and similar to the extracellular domain of the bacterial aspartate receptor and the variant surface glycoprotein from Trypanosoma brucei. Most of the surface-exposed residues of OspC are highly variable among different OspC isolates. The membrane proximal halves of the two long alpha-helices are the only conserved regions that are solvent accessible. As vaccination with recombinant OspC has been shown to elicit a protective immune response in mice, these regions are candidates for peptide-based vaccines.
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<StructureSection load='1g5z' size='340' side='right'caption='[[1g5z]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G5Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g5z OCA], [https://pdbe.org/1g5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g5z RCSB], [https://www.ebi.ac.uk/pdbsum/1g5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g5z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q44717_BORBG Q44717_BORBG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/1g5z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g5z ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1G5Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5Z OCA].
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*[[Outer surface protein|Outer surface protein]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi., Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Hook M, Sacchettini JC, J Biol Chem. 2001 Mar 30;276(13):10010-5. Epub 2001 Jan 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11139584 11139584]
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[[Category: Borreliella burgdorferi]]
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[[Category: Borrelia burgdorferi]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Eicken C]]
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[[Category: Eicken, C.]]
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[[Category: Hook M]]
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[[Category: Hook, M.]]
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[[Category: Klabunde T]]
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[[Category: Klabunde, T.]]
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[[Category: Owens RT]]
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[[Category: Owens, R T.]]
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[[Category: Pikas DS]]
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[[Category: Pikas, D S.]]
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[[Category: Sacchettini JC]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sharma V]]
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[[Category: Sharma, V.]]
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[[Category: alpha helix protein]]
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[[Category: surface protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:30 2008''
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Current revision

CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40

PDB ID 1g5z

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