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1jtf

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[[Image:1jtf.png|left|200px]]
 
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{{STRUCTURE_1jtf| PDB=1jtf | SCENE= }}
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==Crystal Structure Analysis of VP39-F180W mutant and m7GpppG complex==
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<StructureSection load='1jtf' size='340' side='right'caption='[[1jtf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal Structure Analysis of VP39-F180W mutant and m7GpppG complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTF FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12056899}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtf OCA], [https://pdbe.org/1jtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jtf RCSB], [https://www.ebi.ac.uk/pdbsum/1jtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtf ProSAT]</span></td></tr>
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[[1jtf]] is a 1 chain structure of [[Poly(A) Polymerase]] with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTF OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE_VACCW MCE_VACCW] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.<ref>PMID:1313572</ref> <ref>PMID:1670500</ref> <ref>PMID:12359447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jtf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jtf ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Poly(A) Polymerase|Poly(A) Polymerase]]
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*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012056899</ref><references group="xtra"/>
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__TOC__
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[[Category: Polynucleotide adenylyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Gershon, P D.]]
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[[Category: Gershon PD]]
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[[Category: Hu, G.]]
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[[Category: Hu G]]
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[[Category: Oguro, A.]]
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[[Category: Oguro A]]
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[[Category: Quiocho, F A.]]
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[[Category: Quiocho FA]]
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[[Category: Methyltransferase]]
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[[Category: Mrna cap-binding protein]]
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[[Category: Mutant]]
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[[Category: Transferase]]
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[[Category: Vp39]]
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Current revision

Crystal Structure Analysis of VP39-F180W mutant and m7GpppG complex

PDB ID 1jtf

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