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1cwf

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(New page: 200px<br /> <applet load="1cwf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cwf, resolution 1.86&Aring;" /> '''HUMAN CYCLOPHILIN A...)
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[[Image:1cwf.gif|left|200px]]<br />
 
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<applet load="1cwf" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1cwf, resolution 1.86&Aring;" />
 
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'''HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN'''<br />
 
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==Overview==
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==HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN==
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Eight new X-ray structures of different cyclophilin, A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide, a useful structural database for the analysis of protein-ligand, interactions. The effect of small chemical differences on protein-ligand, hydrogen-bonding, van der Waals interactions and water structure is, presented.
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<StructureSection load='1cwf' size='340' side='right'caption='[[1cwf]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cwf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CWF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwf OCA], [https://pdbe.org/1cwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cwf RCSB], [https://www.ebi.ac.uk/pdbsum/1cwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cwf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cwf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cwf ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1CWF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWF OCA]].
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9769216 9769216]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kallen, J.]]
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[[Category: Tolypocladium inflatum]]
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[[Category: Mikol, V.]]
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[[Category: Kallen J]]
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[[Category: Taylor, P.]]
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[[Category: Mikol V]]
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[[Category: Walkinshaw, M.D.]]
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[[Category: Taylor P]]
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[[Category: complex (isomerase/immunosuppressant)]]
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[[Category: Walkinshaw MD]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 16:09:49 2007''
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Current revision

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN

PDB ID 1cwf

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