1z0m
From Proteopedia
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| - | [[Image:1z0m.png|left|200px]] | ||
| - | + | ==the glycogen-binding domain of the AMP-activated protein kinase beta1 subunit== | |
| - | + | <StructureSection load='1z0m' size='340' side='right'caption='[[1z0m]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1z0m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z0M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0m OCA], [https://pdbe.org/1z0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z0m RCSB], [https://www.ebi.ac.uk/pdbsum/1z0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0m ProSAT]</span></td></tr> |
| - | [[1z0m]] is a 3 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AAKB1_RAT AAKB1_RAT] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/1z0m_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z0m ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[AMP-activated protein kinase|AMP-activated protein kinase]] | + | *[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | + | [[Category: Feil SC]] | |
| - | [[Category: Feil | + | [[Category: Gupta A]] |
| - | [[Category: Gupta | + | [[Category: Kemp BE]] |
| - | [[Category: Kemp | + | [[Category: Parker MW]] |
| - | [[Category: Parker | + | [[Category: Polekhina G]] |
| - | [[Category: Polekhina | + | [[Category: Stapleton D]] |
| - | [[Category: Stapleton | + | [[Category: Van Denderen BJ]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
the glycogen-binding domain of the AMP-activated protein kinase beta1 subunit
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