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1od2

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[[Image:1od2.png|left|200px]]
 
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{{STRUCTURE_1od2| PDB=1od2 | SCENE= }}
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==Acetyl-CoA Carboxylase Carboxyltransferase Domain==
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<StructureSection load='1od2' size='340' side='right'caption='[[1od2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===ACETYL-COA CARBOXYLASE CARBOXYLTRANSFERASE DOMAIN===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1od2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OD2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12663926}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1od2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od2 OCA], [https://pdbe.org/1od2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1od2 RCSB], [https://www.ebi.ac.uk/pdbsum/1od2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1od2 ProSAT]</span></td></tr>
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[[1od2]] is a 2 chain structure of [[Acetyl-CoA carboxylase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD2 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1od2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1od2 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012663926</ref><references group="xtra"/>
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__TOC__
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[[Category: Acetyl-CoA carboxylase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Shen, Y.]]
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[[Category: Shen Y]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Acc]]
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[[Category: Acetyl-coa]]
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[[Category: Acetyl-coa carboxylase]]
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[[Category: Ligase]]
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[[Category: Obesity]]
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Current revision

Acetyl-CoA Carboxylase Carboxyltransferase Domain

PDB ID 1od2

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OCA

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