2k6d

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[[Image:2k6d.png|left|200px]]
 
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{{STRUCTURE_2k6d| PDB=2k6d | SCENE= }}
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==CIN85 Sh3-C domain in complex with ubiquitin==
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<StructureSection load='2k6d' size='340' side='right'caption='[[2k6d]]' scene=''>
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===CIN85 Sh3-C domain in complex with ubiquitin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k6d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18680311}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6d OCA], [https://pdbe.org/2k6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6d RCSB], [https://www.ebi.ac.uk/pdbsum/2k6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6d ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2k6d]] is a 2 chain structure of [[Ubiquitin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6D OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SH3K1_HUMAN SH3K1_HUMAN] Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.<ref>PMID:12177062</ref> <ref>PMID:11894095</ref> <ref>PMID:11894096</ref> <ref>PMID:12771190</ref> <ref>PMID:12734385</ref> <ref>PMID:15090612</ref> <ref>PMID:16256071</ref> <ref>PMID:15707590</ref> <ref>PMID:16177060</ref> <ref>PMID:21834987</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/2k6d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k6d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ubiquitin|Ubiquitin]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018680311</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bezsonova, I.]]
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[[Category: Large Structures]]
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[[Category: Forman-Kay, J.]]
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[[Category: Bezsonova I]]
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[[Category: Apoptosis]]
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[[Category: Forman-Kay J]]
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[[Category: Cell junction]]
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[[Category: Cin85]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Cytoskeleton]]
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[[Category: Endocytosis]]
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[[Category: Membrane]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sh3 domain]]
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[[Category: Sh3 domain-ubiquitin complex]]
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[[Category: Sh3-binding]]
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[[Category: Synapse]]
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[[Category: Synaptosome]]
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[[Category: Ubiquitin]]
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Current revision

CIN85 Sh3-C domain in complex with ubiquitin

PDB ID 2k6d

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