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3qj7

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[[Image:3qj7.png|left|200px]]
 
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{{STRUCTURE_3qj7| PDB=3qj7 | SCENE= }}
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==Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP==
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<StructureSection load='3qj7' size='340' side='right'caption='[[3qj7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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[[3qj7]] is a 4 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ7 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qj7 OCA], [https://pdbe.org/3qj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qj7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
==See Also==
==See Also==
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*[[Thymidylate synthase|Thymidylate synthase]]
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Thymidylate synthase]]
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[[Category: Bruning JB]]
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[[Category: Bruning, J B.]]
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[[Category: Harshbarger W]]
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[[Category: Harshbarger, W.]]
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[[Category: Reddy MCM]]
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[[Category: Reddy, M C.M.]]
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[[Category: Sacchettini JC]]
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[[Category: Sacchettini, J C.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Thymidilate synthase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP

PDB ID 3qj7

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