2rd4

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[[Image:2rd4.png|left|200px]]
 
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{{STRUCTURE_2rd4| PDB=2rd4 | SCENE= }}
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==Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution==
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<StructureSection load='2rd4' size='340' side='right'caption='[[2rd4]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
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===Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rd4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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[[2rd4]] is a 3 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd4 OCA], [https://pdbe.org/2rd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2B1_NAJSG PA2B1_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
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[[Category: Kaur, A.]]
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[[Category: Kaur A]]
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[[Category: Kaur, P.]]
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[[Category: Kaur P]]
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[[Category: Mirza, Z.]]
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[[Category: Mirza Z]]
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[[Category: Sharma, S.]]
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[[Category: Sharma S]]
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[[Category: Singh, N.]]
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[[Category: Singh N]]
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[[Category: Singh, T P.]]
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[[Category: Singh TP]]
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[[Category: Sinha, M.]]
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[[Category: Sinha M]]
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[[Category: Srinivasan, A.]]
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[[Category: Srinivasan A]]
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[[Category: Complex]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Metal-binding]]
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[[Category: Peptide inhibitor]]
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[[Category: Phospholipase a2]]
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[[Category: Secreted]]
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Current revision

Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution

PDB ID 2rd4

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OCA

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