2kqc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2kqc" [edit=sysop:move=sysop])
Current revision (09:41, 22 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2kqc.png|left|200px]]
 
-
{{STRUCTURE_2kqc| PDB=2kqc | SCENE= }}
+
==Second PBZ domain of human APLF protein==
 +
<StructureSection load='2kqc' size='340' side='right'caption='[[2kqc]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2kqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQC FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqc OCA], [https://pdbe.org/2kqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqc RCSB], [https://www.ebi.ac.uk/pdbsum/2kqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqc ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/APLF_HUMAN APLF_HUMAN] Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.<ref>PMID:17396150</ref> <ref>PMID:17353262</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/2kqc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kqc ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Addition of poly(ADP-ribose) (PAR) is an important post-translational modification in higher eukaryotes. Several DNA repair and checkpoint proteins possess specific PAR-binding zinc-finger (PBZ) modules critical for function. Here, we present solution structures of the two PBZ modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger. By combining in vivo PAR-binding data with NMR interaction data using PAR fragments, we propose a structural basis for PBZ-PAR recognition.
-
===Second PBZ domain of human APLF protein===
+
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).,Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D Nat Struct Mol Biol. 2010 Feb;17(2):241-3. Epub 2010 Jan 24. PMID:20098424<ref>PMID:20098424</ref>
-
{{ABSTRACT_PUBMED_20098424}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2kqc" style="background-color:#fffaf0;"></div>
-
[[2kqc]] is a 1 chain structure of [[Apurinic/Apyrimidinic Endonuclease-1]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQC OCA].
+
==See Also==
==See Also==
-
*[[Apurinic/Apyrimidinic Endonuclease-1|Apurinic/Apyrimidinic Endonuclease-1]]
+
*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:020098424</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Brockmann, C.]]
+
[[Category: Large Structures]]
-
[[Category: Eustermann, S.]]
+
[[Category: Brockmann C]]
-
[[Category: Neuhaus, D.]]
+
[[Category: Eustermann S]]
-
[[Category: Yang, J.]]
+
[[Category: Neuhaus D]]
-
[[Category: Adp-ribosylation]]
+
[[Category: Yang J]]
-
[[Category: Dna damage]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Lyase]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Zinc-finger]]
+

Current revision

Second PBZ domain of human APLF protein

PDB ID 2kqc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kqc"
Personal tools