1m9r

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[[Image:1m9r.png|left|200px]]
 
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{{STRUCTURE_1m9r| PDB=1m9r | SCENE= }}
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==human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound==
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<StructureSection load='1m9r' size='340' side='right'caption='[[1m9r]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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===human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M9R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12437348}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=INE:3-BROMO-7-NITROINDAZOLE'>INE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m9r OCA], [https://pdbe.org/1m9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m9r RCSB], [https://www.ebi.ac.uk/pdbsum/1m9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m9r ProSAT]</span></td></tr>
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[[1m9r]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9R OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m9/1m9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m9r ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012437348</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Aberg, A.]]
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[[Category: Aberg A]]
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[[Category: Andersson, G.]]
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[[Category: Andersson G]]
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[[Category: Garcin, E D.]]
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[[Category: Garcin ED]]
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[[Category: Getzoff, E D.]]
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[[Category: Getzoff ED]]
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[[Category: Panda, K.]]
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[[Category: Panda K]]
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[[Category: Rosenfeld, R J.]]
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[[Category: Rosenfeld RJ]]
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[[Category: Stuehr, D J.]]
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[[Category: Stuehr DJ]]
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[[Category: Tainer, J A.]]
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[[Category: Tainer JA]]
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[[Category: Wallace, A V.]]
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[[Category: Wallace AV]]
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[[Category: Oxidoreductase]]
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Current revision

human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound

PDB ID 1m9r

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