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1fx8

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[[Image:1fx8.png|left|200px]]
 
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{{STRUCTURE_1fx8| PDB=1fx8 | SCENE= }}
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==CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITH SUBSTRATE GLYCEROL==
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<StructureSection load='1fx8' size='340' side='right'caption='[[1fx8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITH SUBSTRATE GLYCEROL===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The May 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Aquaporin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_5 10.2210/rcsb_pdb/mom_2014_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FX8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11039922}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fx8 OCA], [https://pdbe.org/1fx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fx8 RCSB], [https://www.ebi.ac.uk/pdbsum/1fx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fx8 ProSAT]</span></td></tr>
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[[1fx8]] is a 1 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLPF_ECOLI GLPF_ECOLI] Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fx8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fx8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Aquaporin 3D structures|Aquaporin 3D structures]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011039922</ref><ref group="xtra">PMID:015181215</ref><ref group="xtra">PMID:016792816</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Aquaporin]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Fu, D.]]
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[[Category: Large Structures]]
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[[Category: Libson, A.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Miercke, L J.W.]]
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[[Category: Fu D]]
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[[Category: Nollert, P.]]
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[[Category: Libson A]]
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[[Category: Stroud, R M.]]
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[[Category: Miercke LJW]]
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[[Category: Weitzman, C.]]
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[[Category: Nollert P]]
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[[Category: Glycerol-conducting membrane channel protein]]
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[[Category: Stroud RM]]
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[[Category: Membrane protein]]
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[[Category: Weitzman C]]

Current revision

CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITH SUBSTRATE GLYCEROL

PDB ID 1fx8

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