2vik

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[[Image:2vik.png|left|200px]]
 
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{{STRUCTURE_2vik| PDB=2vik | SCENE= }}
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==REFINED STRUCTURE OF THE ACTIN-SEVERING DOMAIN VILLIN 14T, DETERMINED BY SOLUTION NMR, MINIMIZED AVERAGE STRUCTURE==
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<StructureSection load='2vik' size='340' side='right'caption='[[2vik]]' scene=''>
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===REFINED STRUCTURE OF THE ACTIN-SEVERING DOMAIN VILLIN 14T, DETERMINED BY SOLUTION NMR, MINIMIZED AVERAGE STRUCTURE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VIK FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9194180}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vik OCA], [https://pdbe.org/2vik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vik RCSB], [https://www.ebi.ac.uk/pdbsum/2vik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vik ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2vik]] is a 1 chain structure of [[Villin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIK OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/VILI_CHICK VILI_CHICK] Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.<ref>PMID:3793760</ref> <ref>PMID:1618806</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vik_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vik ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Villin|Villin]]
*[[Villin|Villin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009194180</ref><ref group="xtra">PMID:012217703</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Markus, M A.]]
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[[Category: Large Structures]]
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[[Category: Matsudaira, P.]]
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[[Category: Markus MA]]
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[[Category: Wagner, G.]]
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[[Category: Matsudaira P]]
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[[Category: Actin-binding protein]]
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[[Category: Wagner G]]
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[[Category: Calcium-binding protein]]
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[[Category: Capping protein]]
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[[Category: Cytoskeletal protein]]
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Current revision

REFINED STRUCTURE OF THE ACTIN-SEVERING DOMAIN VILLIN 14T, DETERMINED BY SOLUTION NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 2vik

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