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1dul

From Proteopedia

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[[Image:1dul.png|left|200px]]
 
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{{STRUCTURE_1dul| PDB=1dul | SCENE= }}
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==STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE==
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<StructureSection load='1dul' size='340' side='right'caption='[[1dul]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DUL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10678824}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dul OCA], [https://pdbe.org/1dul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dul RCSB], [https://www.ebi.ac.uk/pdbsum/1dul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dul ProSAT]</span></td></tr>
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[[1dul]] is a 2 chain structure of [[Signal recognition particle protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRP54_ECOLI SRP54_ECOLI] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:2171778</ref> <ref>PMID:1279430</ref> <ref>PMID:1331806</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15140892</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/1dul_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dul ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Signal recognition particle protein|Signal recognition particle protein]]
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*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010678824</ref><ref group="xtra">PMID:016299512</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Batey, R T.]]
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[[Category: Large Structures]]
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[[Category: Doudna, J.]]
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[[Category: Synthetic construct]]
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[[Category: Lucast, L.]]
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[[Category: Batey RT]]
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[[Category: Rambo, R P.]]
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[[Category: Doudna JA]]
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[[Category: Rha, B.]]
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[[Category: Lucast L]]
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[[Category: Double helix]]
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[[Category: Rambo RP]]
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[[Category: Internal loop]]
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[[Category: Rha B]]
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[[Category: Protein-rna complex]]
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[[Category: Ribonucleoprotein]]
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[[Category: Signal recognition particle]]
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[[Category: Signaling protein-rna complex]]
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[[Category: Srp]]
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[[Category: Tetraloop]]
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Current revision

STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE

PDB ID 1dul

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