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4a6l

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[[Image:4a6l.png|left|200px]]
 
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{{STRUCTURE_4a6l| PDB=4a6l | SCENE= }}
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==beta-tryptase inhibitor==
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<StructureSection load='4a6l' size='340' side='right'caption='[[4a6l]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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===beta-tryptase inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4a6l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22192588}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P43:1-{3-[1-({5-[(2-FLUOROPHENYL)ETHYNYL]FURAN-2-YL}CARBONYL)PIPERIDIN-4-YL]PHENYL}METHANAMINE'>P43</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6l OCA], [https://pdbe.org/4a6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6l RCSB], [https://www.ebi.ac.uk/pdbsum/4a6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6l ProSAT]</span></td></tr>
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[[4a6l]] is a 4 chain structure of [[Tryptase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6L OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
==See Also==
==See Also==
*[[Tryptase|Tryptase]]
*[[Tryptase|Tryptase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022192588</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Tryptase]]
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[[Category: Large Structures]]
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[[Category: Maignan, S.]]
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[[Category: Maignan S]]
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[[Category: Mathieu, M.]]
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[[Category: Mathieu M]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Current revision

beta-tryptase inhibitor

PDB ID 4a6l

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