1r26

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[[Image:1r26.png|left|200px]]
 
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{{STRUCTURE_1r26| PDB=1r26 | SCENE= }}
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==Crystal structure of thioredoxin from Trypanosoma brucei brucei==
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<StructureSection load='1r26' size='340' side='right'caption='[[1r26]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R26 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r26 OCA], [https://pdbe.org/1r26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r26 RCSB], [https://www.ebi.ac.uk/pdbsum/1r26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r26 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9NG23_TRYBB Q9NG23_TRYBB]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r26_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r26 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 A resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines. Instead of the common Asp, there is a Trp that binds an ordered water molecule probably involved in the protonation/deprotonation of the more buried cysteine during catalysis. The conserved Trp in the WCGPC sequence motif has an exposed position that can interact with target proteins.
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===Crystal structure of thioredoxin from Trypanosoma brucei brucei===
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Structure of thioredoxin from Trypanosoma brucei brucei.,Friemann R, Schmidt H, Ramaswamy S, Forstner M, Krauth-Siegel RL, Eklund H FEBS Lett. 2003 Nov 20;554(3):301-5. PMID:14623083<ref>PMID:14623083</ref>
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{{ABSTRACT_PUBMED_14623083}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1r26" style="background-color:#fffaf0;"></div>
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[[1r26]] is a 1 chain structure of [[Thioredoxin]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma Trypanosoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R26 OCA].
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==See Also==
==See Also==
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*[[Thioredoxin|Thioredoxin]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014623083</ref><references group="xtra"/>
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__TOC__
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[[Category: Trypanosoma]]
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</StructureSection>
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[[Category: Eklund, H.]]
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[[Category: Large Structures]]
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[[Category: Forstner, M.]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Friemann, R.]]
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[[Category: Eklund H]]
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[[Category: Krauth-Siegel, R L.]]
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[[Category: Forstner M]]
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[[Category: Ramaswamy, S.]]
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[[Category: Friemann R]]
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[[Category: Schmidt, H.]]
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[[Category: Krauth-Siegel RL]]
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[[Category: Electron transport]]
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[[Category: Ramaswamy S]]
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[[Category: Redox-active disulfide]]
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[[Category: Schmidt H]]
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[[Category: Thioredoxin]]
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Current revision

Crystal structure of thioredoxin from Trypanosoma brucei brucei

PDB ID 1r26

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