2eko

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[[Image:2eko.png|left|200px]]
 
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{{STRUCTURE_2eko| PDB=2eko | SCENE= }}
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==Solution structure of RUH-073, a Pseudo Chromo Domain from Human cDNA==
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<StructureSection load='2eko' size='340' side='right'caption='[[2eko]]' scene=''>
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===Solution structure of RUH-073, a Pseudo Chromo Domain from Human cDNA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EKO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eko OCA], [https://pdbe.org/2eko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eko RCSB], [https://www.ebi.ac.uk/pdbsum/2eko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eko ProSAT], [https://www.topsan.org/Proteins/RSGI/2eko TOPSAN]</span></td></tr>
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[[2eko]] is a 1 chain structure of [[Histone acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EKO OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT5_HUMAN KAT5_HUMAN] Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.<ref>PMID:12776177</ref> <ref>PMID:15310756</ref> <ref>PMID:14966270</ref> <ref>PMID:15121871</ref> <ref>PMID:15042092</ref> <ref>PMID:16141325</ref> <ref>PMID:16387653</ref> <ref>PMID:17996965</ref> <ref>PMID:19909775</ref> <ref>PMID:24463511</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/2eko_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eko ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Histone acetyltransferase|Histone acetyltransferase]]
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F.]]
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[[Category: Large Structures]]
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[[Category: Hirota, H.]]
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[[Category: Hayashi F]]
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[[Category: Momen, A Z.M Ruhul.]]
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[[Category: Hirota H]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Ruhul Momen AZM]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Chromatin organization modifier]]
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[[Category: Chromo domain]]
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[[Category: Histone tail]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Solution structure of RUH-073, a Pseudo Chromo Domain from Human cDNA

PDB ID 2eko

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