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1gnd

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[[Image:1gnd.gif|left|200px]]<br /><applet load="1gnd" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gnd, resolution 1.81&Aring;" />
 
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'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''<br />
 
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==Overview==
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==GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM==
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The crystal structure of the bovine alpha-isoform of Rab GDP-dissociation inhibitor (GDI), which functions in vesicle-membrane transport to recycle and regulate Rab GTPases, has been determined to a resolution of 1.81 A. GDI is constructed of two main structural units, a large complex multisheet domain I and a smaller alpha-helical domain II. The structural organization of domain I is surprisingly closely related to FAD-containing monooxygenases and oxidases. Sequence-conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the molecule. The two most sequence-conserved regions, which form a compact structure at the apex of GDI, are shown by site-directed mutagenesis to play a critical role in the binding of Rab proteins.
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<StructureSection load='1gnd' size='340' side='right'caption='[[1gnd]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GND FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnd OCA], [https://pdbe.org/1gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnd RCSB], [https://www.ebi.ac.uk/pdbsum/1gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GDIA_BOVIN GDIA_BOVIN] Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gnd ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1GND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA].
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*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8609986 8609986]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Balch, W E.]]
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[[Category: Balch WE]]
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[[Category: Huang, M.]]
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[[Category: Huang M]]
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[[Category: Metteson, J.]]
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[[Category: Metteson J]]
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[[Category: Schalk, I.]]
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[[Category: Schalk I]]
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[[Category: Stura, E A.]]
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[[Category: Stura EA]]
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[[Category: Tandon, A.]]
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[[Category: Tandon A]]
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[[Category: Wilson, I A.]]
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[[Category: Wilson IA]]
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[[Category: Wu, S K.]]
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[[Category: Wu S-K]]
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[[Category: Zeng, K.]]
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[[Category: Zeng K]]
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[[Category: gtpase activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:51:54 2008''
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Current revision

GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM

PDB ID 1gnd

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